Yes. Inadequate sightlines, intensification of access onto a national road, or an entrance that would endanger road users are common grounds for refusal, and they are among the hardest to overcome on appeal.
National policy restricts new accesses onto national primary and secondary roads outside speed limit zones. Where that policy applies, the objection carries significant weight regardless of how well the entrance is designed.
For local and regional roads, the question is usually whether the required visibility can be achieved. Where it can, an entrance redesign or a change of position on the site frontage often resolves the issue.